Simulating a Trial: Can Bicarb Save Lives?
For decades, the use of sodium bicarbonate in the ICU has been a clinical paradox. While physiologically logical to buffer life-threatening acidosis, large-scale evidence for a mortality benefit has remained frustratingly elusive. A recent study by the Queensland Critical Care Research Network (QCCRN) has now stepped into this gap, utilizing a sophisticated "target trial emulation" to analyze real-world data from over 6,000 patients across 12 Australian ICUs.
4/7/2026
